Prostate Cancer: identify cancer risk gene test?

Certain variations in the human genome can increase the risk for cancer of the prostate

Prostate Cancer: identify cancer risk gene test?

Still no genetic test for prostate cancer. (source: © Catalin - Fotolia)

Why in some men in the course of life changed the prostate and tumors arise, is not yet known. There are some risk factors, favor the disease. Among others, there appears to be a familial predisposition for Prostate Cancer to give.

Cancer is on the Prostate inheritable?

About half of all men come from 50. Age changes in the prostate. These can be benign or malignant. In men, have their close male relatives or had prostate cancer, the risk is increased, to fall ill from prostate cancer. This speaks for a genetic component in the development of prostate cancer.

Especially, if several family members are ill and the disease in relatively young age occurs, experts expect a familial predisposition from.

Is there a genetic test, with the help of which can assess on the prostate cancer risk?

Unlike other cancers (For example, breast cancer) there is for prostate cancer not make genetic testing, can quantify the risk of disease a patient. However, there are recent studies, have identified certain risk genes for prostate cancer. A research team from the UK has in a 2018 published genome-wide association study the genes of some 80.000 Men with prostate cancer and 60.000 Men without prostate cancer compared.(1) The scientists found about 60 so-called single nucleotide polymorphisms (SNP), So inherited genetic variants, which are associated with an increased risk of prostate cancer. Together with already known variants the researchers chose 147 for research purposes genes and developed from them a genetic test. In their study, this test was about 28 explain percent of prostate disease. For a concrete forecast that not enough, but the development of an appropriate genetic testing for potential risk patients so is within reach.

It is conceivable, that there is a genetic test in the future, can undergo which family preloaded Men. this shows a high risk, might be advised for example to earlier and more comprehensive screenings to men affected.

(1.) Fredrick R. Schumacher, Ali Amin Al Olama, Rosalind A. Eeles: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. In: Nature Geneticsvolume 50, pages928-936 (2018).

source: © Catalin - Fotolia

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